Why testing for AML mutations is important
For certain types of targeted therapy, it’s important to know about specific genetic mutations that may be present in the type of AML that you have. Targeted therapies are often designed to work on cells that have a specific mutation, so if your healthcare professional knows if you have a mutation, they may be able to offer an additional treatment option.
What are genetic mutations?1
When cancer occurs, the cancer cells may have specific gene changes called mutations that trigger the cells to divide and grow. Medical researchers have developed targeted treatments that fight cancer cells with specific mutations. These treatments only work if their specific mutation is present.
Biomarker mutation testing1
Biomarker mutation testing will look for specific changes in DNA (genetic mutations) in the cancer cells. Testing may involve sending a sample of your tumor blood (collected via biopsy) or a blood sample to a laboratory. Your doctor will order the appropriate genetic testing for your case.
Ask your doctor about testing for AML subtypes and mutations
To make sure you know about all the AML treatment options that are possible be sure to ask your doctor to confirm your AML subtype based on classification and about testing for genetic mutations using a biomarker test. In particular, there are targeted treatments designed to work in people with AML who test positive for the IDH mutation.
Download our Support for Your AML Journey brochure
Learn about the range of treatment options for AML, including mutation-targeted therapies, in this brochure.
References
1. Biomarker Tests and Cancer Treatment. American Cancer Society.
https://www.cancer.org/treatment/understanding-your-diagnosis/tests/biomarker-tests.html. Updated September 21, 2022. Accessed February 13, 2023.